View source for 7cg4


==Cryo-EM structure of the flagellar export apparatus with FliE from Salmonella==
<StructureSection load='7cg4' size='340' side='right'caption='[[7cg4]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7cg4]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium_str._LT2 Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CG4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CG4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cg4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cg4 OCA], [https://pdbe.org/7cg4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cg4 RCSB], [https://www.ebi.ac.uk/pdbsum/7cg4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cg4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FLIE_SALTY FLIE_SALTY] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The bacterial flagellar motor is a supramolecular protein machine that drives rotation of the flagellum for motility, which is essential for bacterial survival in different environments and a key determinant of pathogenicity. The detailed structure of the flagellar motor remains unknown. Here we present an atomic-resolution cryoelectron microscopy (cryo-EM) structure of the bacterial flagellar motor complexed with the hook, consisting of 175 subunits with a molecular mass of approximately 6.3 MDa. The structure reveals that 10 peptides protruding from the MS ring with the FlgB and FliE subunits mediate torque transmission from the MS ring to the rod and overcome the symmetry mismatch between the rotational and helical structures in the motor. The LP ring contacts the distal rod and applies electrostatic forces to support its rotation and torque transmission to the hook. This work provides detailed molecular insights into the structure, assembly, and torque transmission mechanisms of the flagellar motor.

Structural basis of assembly and torque transmission of the bacterial flagellar motor.,Tan J, Zhang X, Wang X, Xu C, Chang S, Wu H, Wang T, Liang H, Gao H, Zhou Y, Zhu Y Cell. 2021 Apr 14. pii: S0092-8674(21)00430-X. doi: 10.1016/j.cell.2021.03.057. PMID:33882274<ref>PMID:33882274</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7cg4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium str. LT2]]
[[Category: Chang SH]]
[[Category: Tan JX]]
[[Category: Wang XF]]
[[Category: Xu CH]]
[[Category: Zhang X]]
[[Category: Zhou Y]]
[[Category: Zhu YQ]]