View source for 7cjx


==UDP-glucuronosyltransferase 2B15 C-terminal domain-L446S==
<StructureSection load='7cjx' size='340' side='right'caption='[[7cjx]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7cjx]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CJX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CJX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.986414&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cjx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cjx OCA], [https://pdbe.org/7cjx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cjx RCSB], [https://www.ebi.ac.uk/pdbsum/7cjx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cjx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/UDB15_HUMAN UDB15_HUMAN] UDPGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. This isozyme displays activity toward several classes of xenobiotic substrates, including simple phenolic compounds, 7-hydroxylated coumarins, flavonoids, anthraquinones, and certain drugs and their hydroxylated metabolites. It also catalyzes the glucuronidation of endogenous estrogens and androgens.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Wang CY]]
[[Category: Zhang L]]