View source for 7crz


==Crystal structure of human glucose transporter GLUT3 bound with C3361==
<StructureSection load='7crz' size='340' side='right'caption='[[7crz]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7crz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CRZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CRZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=F00:(2S,3R,4S,5R,6R)-6-(hydroxymethyl)-4-undec-10-enoxy-oxane-2,3,5-triol'>F00</scene>, <scene name='pdbligand=OLC:(2R)-2,3-DIHYDROXYPROPYL+(9Z)-OCTADEC-9-ENOATE'>OLC</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7crz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7crz OCA], [https://pdbe.org/7crz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7crz RCSB], [https://www.ebi.ac.uk/pdbsum/7crz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7crz ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GTR3_HUMAN GTR3_HUMAN] Huntington disease. 
== Function ==
[https://www.uniprot.org/uniprot/GTR3_HUMAN GTR3_HUMAN] Facilitative glucose transporter. Probably a neuronal glucose transporter.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Artemisinin-resistant malaria parasites have emerged and have been spreading, posing a significant public health challenge. Antimalarial drugs with novel mechanisms of action are therefore urgently needed. In this report, we exploit a "selective starvation" strategy by inhibiting Plasmodium falciparum hexose transporter 1 (PfHT1), the sole hexose transporter in P. falciparum, over human glucose transporter 1 (hGLUT1), providing an alternative approach to fight against multidrug-resistant malaria parasites. The crystal structure of hGLUT3, which shares 80% sequence similarity with hGLUT1, was resolved in complex with C3361, a moderate PfHT1-specific inhibitor, at 2.3-A resolution. Structural comparison between the present hGLUT3-C3361 and our previously reported PfHT1-C3361 confirmed the unique inhibitor binding-induced pocket in PfHT1. We then designed small molecules to simultaneously block the orthosteric and allosteric pockets of PfHT1. Through extensive structure-activity relationship studies, the TH-PF series was identified to selectively inhibit PfHT1 over hGLUT1 and potent against multiple strains of the blood-stage P. falciparum Our findings shed light on the next-generation chemotherapeutics with a paradigm-shifting structure-based design strategy to simultaneously target the orthosteric and allosteric sites of a transporter.

Orthosteric-allosteric dual inhibitors of PfHT1 as selective antimalarial agents.,Huang J, Yuan Y, Zhao N, Pu D, Tang Q, Zhang S, Luo S, Yang X, Wang N, Xiao Y, Zhang T, Liu Z, Sakata-Kato T, Jiang X, Kato N, Yan N, Yin H Proc Natl Acad Sci U S A. 2021 Jan 19;118(3). pii: 2017749118. doi:, 10.1073/pnas.2017749118. PMID:33402433<ref>PMID:33402433</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7crz" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Jiang X]]
[[Category: Wang N]]
[[Category: Yan N]]
[[Category: Yuan YY]]
[[Category: Zhang S]]