View source for 7cvx


==Crystal structure of Catechol o-methyl transferase (COMT) from Niastella koreensis==
<StructureSection load='7cvx' size='340' side='right'caption='[[7cvx]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7cvx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Niastella_koreensis_GR20-10 Niastella koreensis GR20-10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7CVX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7CVX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DHB:3,4-DIHYDROXYBENZOIC+ACID'>DHB</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7cvx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7cvx OCA], [https://pdbe.org/7cvx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7cvx RCSB], [https://www.ebi.ac.uk/pdbsum/7cvx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7cvx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAMT_NIAKG CAMT_NIAKG] Catechol O-methyltransferase that can use various catechol-like compounds (PubMed:33596655). Can produce vanillic acid (meta-form) and iso-vanillic acid (para-form) from protocatechuic acid (PCA) (PubMed:33596655). Does not have a regiospecificity, and produces the meta- and para-forms of the products in equal proportion (PubMed:33596655).<ref>PMID:33596655</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Niastella koreensis GR20-10]]
[[Category: Kim B]]
[[Category: Kim K-J]]
[[Category: Lee SH]]