View source for 7dcp


==cryo-EM structure of the DEAH-box helicase Prp2 and coactivator Spp2==
<StructureSection load='7dcp' size='340' side='right'caption='[[7dcp]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7dcp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DCP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DCP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.15&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dcp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dcp OCA], [https://pdbe.org/7dcp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dcp RCSB], [https://www.ebi.ac.uk/pdbsum/7dcp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dcp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PRP2_YEAST PRP2_YEAST] Involved in pre-mRNA splicing. Is required together with ATP and at least one other factor, for the first cleavage-ligation reaction. Functions as a molecular motor in the activation of the precatalytic spliceosome for the first transesterification reaction of pre-mRNA splicing by hydrolyzing ATP to cause the activation of the spliceosome without the occurrence of splicing. Capable of hydrolyzing nucleoside triphosphates in the presence of single-stranded RNAs such as poly(U).<ref>PMID:14730020</ref> <ref>PMID:1534753</ref> <ref>PMID:2251118</ref> <ref>PMID:8112302</ref> <ref>PMID:8943336</ref> 

==See Also==
*[[Helicase 3D structures|Helicase 3D structures]]
*[[Pre-mRNA splicing factors 3D structures|Pre-mRNA splicing factors 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Bai R]]
[[Category: Jia Q]]
[[Category: Lei J]]
[[Category: Shi Y]]
[[Category: Wan R]]
[[Category: Yan C]]
[[Category: Zhang P]]