View source for 7dhg


==Crystal structure of SARS-CoV-2 Orf9b complex with human TOM70==
<StructureSection load='7dhg' size='340' side='right'caption='[[7dhg]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7dhg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Severe_acute_respiratory_syndrome_coronavirus_2 Severe acute respiratory syndrome coronavirus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DHG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DHG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dhg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dhg OCA], [https://pdbe.org/7dhg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dhg RCSB], [https://www.ebi.ac.uk/pdbsum/7dhg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dhg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TOM70_HUMAN TOM70_HUMAN] Acts as receptor of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) (PubMed:12526792). Recognizes and mediates the translocation of mitochondrial preproteins from the cytosol into the mitochondria in a chaperone dependent manner (PubMed:12526792, PubMed:35025629). Mediates TBK1 and IRF3 activation induced by MAVS in response to Sendai virus infection and promotes host antiviral responses during virus infection (PubMed:20628368, PubMed:25609812, PubMed:32728199). Upon Sendai virus infection, recruits HSP90AA1:IRF3:BAX in mitochondrion and the complex induces apoptosis (PubMed:25609812).<ref>PMID:12526792</ref> <ref>PMID:20628368</ref> <ref>PMID:25609812</ref> <ref>PMID:32728199</ref> <ref>PMID:35025629</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Severe acute respiratory syndrome coronavirus 2]]
[[Category: Cui S]]
[[Category: Gao X]]
[[Category: Olieric V]]
[[Category: Qin B]]
[[Category: Wang M]]
[[Category: Zhu K]]