View source for 7dn2


==Acidic stable capsid structure of Helicobacter pylori bacteriophage KHP30==
<SX load='7dn2' size='340' side='right' viewer='molstar' caption='[[7dn2]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7dn2]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Helicobacter_phage_KHP30 Helicobacter phage KHP30]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DN2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DN2 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dn2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dn2 OCA], [https://pdbe.org/7dn2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dn2 RCSB], [https://www.ebi.ac.uk/pdbsum/7dn2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dn2 ProSAT]</span></td></tr>
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== Function ==
[https://www.uniprot.org/uniprot/ORF14_BPKHP ORF14_BPKHP] 
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== Publication Abstract from PubMed ==
The acid-stable capsid structures of Helicobacter pylori phages KHP30 and KHP40 are solved at 2.7 and 3.0 A resolutions by cryoelectron microscopy, respectively. The capsids have icosahedral T = 9 symmetry and consist of each 540 copies of 2 structural proteins, a major capsid protein, and a cement protein. The major capsid proteins form 12 pentagonal capsomeres occupying icosahedral vertexes and 80 hexagonal capsomeres located at icosahedral faces and edges. The major capsid protein has a unique protruding loop extending to the neighboring subunit that stabilizes hexagonal capsomeres. Furthermore, the capsid is decorated with trimeric cement proteins with a jelly roll motif. The cement protein trimer sits on the quasi-three-fold axis formed by three major capsid protein capsomeres, thereby enhancing the particle stability by connecting these capsomeres. Sequence and structure comparisons between the related Helicobacter pylori phages suggest a possible mechanism of phage adaptation to the human gastric environment.

Acid-stable capsid structure of Helicobacter pylori bacteriophage KHP30 by single-particle cryoelectron microscopy.,Kamiya R, Uchiyama J, Matsuzaki S, Murata K, Iwasaki K, Miyazaki N Structure. 2021 Sep 27. pii: S0969-2126(21)00329-4. doi:, 10.1016/j.str.2021.09.001. PMID:34597601<ref>PMID:34597601</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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[[Category: Helicobacter phage KHP30]]
[[Category: Large Structures]]
[[Category: Iwasaki K]]
[[Category: Kamiya R]]
[[Category: Matsuzaki S]]
[[Category: Miyazaki N]]
[[Category: Murata K]]
[[Category: Uchiyama J]]