View source for 7dpa


==Cryo-EM structure of the human ELMO1-DOCK5-Rac1 complex==
<StructureSection load='7dpa' size='340' side='right'caption='[[7dpa]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7dpa]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DPA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DPA FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dpa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dpa OCA], [https://pdbe.org/7dpa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dpa RCSB], [https://www.ebi.ac.uk/pdbsum/7dpa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dpa ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DOCK5_HUMAN DOCK5_HUMAN] Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP (By similarity). Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).[UniProtKB:B2RY04]<ref>PMID:19004829</ref> 

==See Also==
*[[Dedicator of cytokinesis protein 3D structures|Dedicator of cytokinesis protein 3D structures]]
*[[Rac 3D structures|Rac 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Ehara H]]
[[Category: Hanada K]]
[[Category: Ikeda M]]
[[Category: Katsura K]]
[[Category: Kaushik R]]
[[Category: Kukimoto-Niino M]]
[[Category: Mishima-Tsumagari C]]
[[Category: Shirouzu M]]
[[Category: Uchikubo-Kamo T]]
[[Category: Yokoyama T]]
[[Category: Yonemochi M]]
[[Category: Zhang KYJ]]