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==Cryo-EM structure of CAR triggered Coxsackievirus B1 A-particle==
<StructureSection load='7dq4' size='340' side='right'caption='[[7dq4]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7dq4]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Coxsackievirus_B1 Coxsackievirus B1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7DQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7DQ4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7dq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7dq4 OCA], [https://pdbe.org/7dq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7dq4 RCSB], [https://www.ebi.ac.uk/pdbsum/7dq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7dq4 ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Enterovirus uncoating receptors bind at the surface depression ("canyon") that encircles each capsid vertex causing the release of a host-derived lipid called "pocket factor" that is buried in a hydrophobic pocket formed by the major viral capsid protein, VP1. Coxsackievirus and adenovirus receptor (CAR) is a universal uncoating receptor of group B coxsackieviruses (CVB). Here, we present five high-resolution cryoEM structures of CVB representing different stages of virus infection. Structural comparisons show that the CAR penetrates deeper into the canyon than other uncoating receptors, leading to a cascade of events: collapse of the VP1 hydrophobic pocket, high-efficiency release of the pocket factor and viral uncoating and genome release under neutral pH, as compared with low pH. Furthermore, we identified a potent therapeutic antibody that can neutralize viral infection by interfering with virion-CAR interactions, destabilizing the capsid and inducing virion disruption. Together, these results define the structural basis of CVB cell entry and antibody neutralization.

Cryo-EM structures reveal the molecular basis of receptor-initiated coxsackievirus uncoating.,Xu L, Zheng Q, Zhu R, Yin Z, Yu H, Lin Y, Wu Y, He M, Huang Y, Jiang Y, Sun H, Zha Z, Yang H, Huang Q, Zhang D, Chen Z, Ye X, Han J, Yang L, Liu C, Que Y, Fang M, Gu Y, Zhang J, Luo W, Zhou ZH, Li S, Cheng T, Xia N Cell Host Microbe. 2021 Mar 10;29(3):448-462.e5. doi: 10.1016/j.chom.2021.01.001. , Epub 2021 Feb 3. PMID:33539764<ref>PMID:33539764</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Coxsackievirus B1]]
[[Category: Large Structures]]
[[Category: Cheng T]]
[[Category: Li S]]
[[Category: Xu L]]
[[Category: Zheng Q]]
[[Category: Zhu R]]