View source for 7euc


==Parallel G-quadruplex structure==
<StructureSection load='7euc' size='340' side='right'caption='[[7euc]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7euc]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7EUC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7EUC FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PSE:O-PHOSPHOETHANOLAMINE'>PSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7euc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7euc OCA], [https://pdbe.org/7euc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7euc RCSB], [https://www.ebi.ac.uk/pdbsum/7euc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7euc ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
A four-stranded scaffold of nucleic acids termed G-quadruplex (G4) has found growing applications in nano- and biotechnology. Propeller loops are a hallmark of the most stable intramolecular parallel-stranded G4s. To date, propeller loops have been observed to span only a maximum of three G-tetrad layers. Going beyond that would allow creation of more stable scaffolds useful for building robust nanodevices. Here we investigate the formation of propeller loops spanning more than three layers. We show that native nucleotide sequences are incompatible toward this goal, and we report on synthetic non-nucleotide linkers that form a propeller loop across four layers. With the established linkers, we constructed a four-layered intramolecular parallel-stranded G4, which exhibited ultrahigh thermal stability. Control on loop design would augment the toolbox toward engineering of G4-based nanoscaffolds for diverse applications.

Four-Layered Intramolecular Parallel G-Quadruplex with Non-Nucleotide Loops: An Ultra-Stable Self-Folded DNA Nano-Scaffold.,Devi G, Winnerdy FR, Ang JCY, Lim KW, Phan AT ACS Nano. 2022 Jan 25;16(1):533-540. doi: 10.1021/acsnano.1c07630. Epub 2021 Dec , 20. PMID:34927423<ref>PMID:34927423</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7euc" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Ang JCY]]
[[Category: Devi G]]
[[Category: Lim KW]]
[[Category: Phan AT]]
[[Category: Winnerdy FR]]