View source for 7fbi


==Cryo-EM structure of EBV gB in complex with nAbs 3A3 and 3A5==
<StructureSection load='7fbi' size='340' side='right'caption='[[7fbi]], [[Resolution|resolution]] 3.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7fbi]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_4 Human gammaherpesvirus 4] and [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FBI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FBI FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fbi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fbi OCA], [https://pdbe.org/7fbi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fbi RCSB], [https://www.ebi.ac.uk/pdbsum/7fbi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fbi ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GB_EBVG GB_EBVG] Envelope glycoprotein that forms spikes at the surface of virion envelope. Essential for the initial attachment to heparan sulfate moieties of the host cell surface proteoglycans. Involved in fusion of viral and cellular membranes leading to virus entry into the host cell. Following initial binding to its host receptors, membrane fusion is mediated by the fusion machinery composed at least of gB and the heterodimer gH/gL. May be involved in the fusion between the virion envelope and the outer nuclear membrane during virion egress.[HAMAP-Rule:MF_04032]

==See Also==
*[[Antibody 3D structures|Antibody 3D structures]]
*[[Glycoproteins B and D|Glycoproteins B and D]]
__TOC__
</StructureSection>
[[Category: Human gammaherpesvirus 4]]
[[Category: Large Structures]]
[[Category: Oryctolagus cuniculus]]
[[Category: Chen Y]]
[[Category: Hong J]]
[[Category: Li S]]
[[Category: Zha Z]]
[[Category: Zhang X]]
[[Category: Zheng Q]]