View source for 7feo


==Crystal structure of AtMBD5 MBD domain==
<StructureSection load='7feo' size='340' side='right'caption='[[7feo]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7feo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arabidopsis_thaliana Arabidopsis thaliana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FEO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FEO FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7feo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7feo OCA], [https://pdbe.org/7feo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7feo RCSB], [https://www.ebi.ac.uk/pdbsum/7feo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7feo ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/MBD5_ARATH MBD5_ARATH] Transcriptional regulator that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. In addition, binds specifically methylated m(5)CpNpN but not m(5)CpNpG (N is A, T or C). Plays probably a role in gene silencing.<ref>PMID:12787239</ref> <ref>PMID:14605234</ref> <ref>PMID:15010609</ref> 

==See Also==
*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arabidopsis thaliana]]
[[Category: Large Structures]]
[[Category: Liu K]]
[[Category: Min JR]]
[[Category: Wu ZB]]
[[Category: Zhou MQ]]