View source for 7fhi


==Interaction between a fluoroquinolone derivative and RNAs with a single bulge==
<StructureSection load='7fhi' size='340' side='right'caption='[[7fhi]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7fhi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FHI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FHI FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=53D:1-cyclopropyl-N-[3-(dimethylamino)propyl]-7-(4-ethylpiperazin-1-yl)-6-fluoranyl-4-oxidanylidene-quinoline-3-carboxamide'>53D</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fhi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fhi OCA], [https://pdbe.org/7fhi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fhi RCSB], [https://www.ebi.ac.uk/pdbsum/7fhi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fhi ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Interaction analysis between small molecules and RNA as well as structure determination of RNA-small molecule complexes will be the clues to search for compounds that bind to specific mRNA or non-coding RNA in drug discovery. In this study, the RNA binding ability of a fluoroquinolone derivative, KG022, was examined against single-residue bulge-containing hairpin RNAs as RNA models. NMR analysis indicated that KG022 interacts with the RNAs in the vicinity of the bulge residue, with preferring C and G as the bulge residues. The solution structures of the RNA-KG022 complexes showed that the KG022 binds to the RNAs at the bulge-out regions. Each substituent in KG022 interacts specific position of RNAs around the bulge-out region probably contributing the specificity of the binding. This work provides a novel member for the RNA-targeted small molecules.

Interaction between a fluoroquinolone derivative and RNAs with a single bulge.,Nagano K, Kamimura T, Kawai G J Biochem. 2021 Nov 16. pii: 6429710. doi: 10.1093/jb/mvab124. PMID:34791286<ref>PMID:34791286</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7fhi" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Kamimura T]]
[[Category: Kawai G]]
[[Category: Nagano K]]