View source for 7fib


==Crystal structure of the regulatory domain of AceR in Acinetobacter baumannii==
<StructureSection load='7fib' size='340' side='right'caption='[[7fib]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7fib]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acinetobacter_baumannii Acinetobacter baumannii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FIB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FIB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BR:BROMIDE+ION'>BR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fib FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fib OCA], [https://pdbe.org/7fib PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fib RCSB], [https://www.ebi.ac.uk/pdbsum/7fib PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fib ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ACER_ACIBT ACER_ACIBT] Regulates the expression of the AceI transporter (PubMed:29481596). Binds DNA and chlorhexidine (PubMed:29481596, PubMed:32636271). Binds to regulatory sites within the intergenic region between the aceI and aceR genes, and affects the interaction between RNA polymerase (RNAP) and promoter DNA both in the presence and in the absence of chlorhexidine (PubMed:29481596, PubMed:32636271). In the absence of chlorhexidine, prevents transcription of the aceI gene by disrupting interactions between the promoter DNA and RNAP (PubMed:32636271). In the presence of chlorhexidine, activates expression of aceI (PubMed:29481596, PubMed:32636271). When AceR interacts with chlorhexidine, it undergoes a conformational change and the tetrameric form either releases the DNA or shifts the position of the DNA-binding region to allow RNAP to bind onto the promoter DNA to proceed with aceI transcription (PubMed:32636271).<ref>PMID:29481596</ref> <ref>PMID:32636271</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Acinetobacter baumannii]]
[[Category: Large Structures]]
[[Category: Chi P]]
[[Category: Guo L]]