View source for 7fj1


==Cryo-EM structure of pseudorabies virus C-capsid==
<SX load='7fj1' size='340' side='right' viewer='molstar' caption='[[7fj1]], [[Resolution|resolution]] 4.43&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7fj1]] is a 51 chain structure with sequence from [https://en.wikipedia.org/wiki/Suid_alphaherpesvirus_1 Suid alphaherpesvirus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FJ1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FJ1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.43&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fj1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fj1 OCA], [https://pdbe.org/7fj1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fj1 RCSB], [https://www.ebi.ac.uk/pdbsum/7fj1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fj1 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/G3G8T2_SUHV G3G8T2_SUHV] 
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== Publication Abstract from PubMed ==
Pseudorabies virus (PRV) is a major etiological agent of swine infectious diseases and is responsible for significant economic losses in the swine industry. Recent data points to human viral encephalitis caused by PRV infection, suggesting that PRV may be able to overcome the species barrier to infect humans. To date, there is no available therapeutic for PRV infection. Here, we report the near-atomic structures of the PRV A-capsid and C-capsid, and illustrate the interaction that occurs between these subunits. We show that the C-capsid portal complex is decorated with capsid-associated tegument complexes. The PRV capsid structure is highly reminiscent of other alpha-herpesviruses, with some additional structural features of beta- and gamma-herpesviruses. These results illustrate the structure of the PRV capsid and elucidate the underlying assembly mechanism at the molecular level. This knowledge may be useful for the development of oncolytic agents or specific therapeutics against this arm of the herpesvirus family.

Structures of pseudorabies virus capsids.,Wang G, Zha Z, Huang P, Sun H, Huang Y, He M, Chen T, Lin L, Chen Z, Kong Z, Que Y, Li T, Gu Y, Yu H, Zhang J, Zheng Q, Chen Y, Li S, Xia N Nat Commun. 2022 Mar 22;13(1):1533. doi: 10.1038/s41467-022-29250-3. PMID:35318331<ref>PMID:35318331</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 7fj1" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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[[Category: Large Structures]]
[[Category: Suid alphaherpesvirus 1]]
[[Category: Li S]]
[[Category: Sun H]]
[[Category: Zha Z]]
[[Category: Zheng Q]]