View source for 7fsf


==CRYSTAL STRUCTURE OF T. MARITIMA REVERSE GYRASE ACTIVE SITE VARIANT Y851F==
<StructureSection load='7fsf' size='340' side='right'caption='[[7fsf]], [[Resolution|resolution]] 2.77&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7fsf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima_MSB8 Thermotoga maritima MSB8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FSF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FSF FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.77&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fsf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fsf OCA], [https://pdbe.org/7fsf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fsf RCSB], [https://www.ebi.ac.uk/pdbsum/7fsf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fsf ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RGYR_THEMA RGYR_THEMA] Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Thermotoga maritima MSB8]]
[[Category: Klostermeier D]]
[[Category: Kummel D]]
[[Category: Rasche R]]
[[Category: Rudolph MG]]