View source for 7fuz


==PanDDA analysis group deposition -- PHIP in complex with Z4307421429==
<StructureSection load='7fuz' size='340' side='right'caption='[[7fuz]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7fuz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FUZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FUZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZK0:~{N}-~{tert}-butyl-4-(2,3,3-trimethylindol-5-yl)carbonyl-piperazine-1-carboxamide'>ZK0</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7fuz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7fuz OCA], [https://pdbe.org/7fuz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7fuz RCSB], [https://www.ebi.ac.uk/pdbsum/7fuz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7fuz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PHIP_HUMAN PHIP_HUMAN] Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization.<ref>PMID:12242307</ref> <ref>PMID:21834987</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Biggin PC]]
[[Category: Bradshaw WJ]]
[[Category: Fearon D]]
[[Category: Grosjean H]]
[[Category: Koekemoer L]]
[[Category: Krojer T]]
[[Category: Tomlinson C]]
[[Category: Von Delft F]]