View source for 7h63


==THE 1.65 A CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH 4-[(5-fluoro-3-propan-2-yl-1H-indol-2-yl)-phenylmethyl]-3-hydroxy-2-propan-2-yl-1,2-dihydropyrrol-5-one (VINYLOGOUS ACID)==
<StructureSection load='7h63' size='340' side='right'caption='[[7h63]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7h63]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7H63 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7H63 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.65&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AOZ:(2~{R})-4-[(~{R})-(5-fluoranyl-3-propan-2-yl-1~{H}-indol-2-yl)-phenyl-methyl]-3-oxidanyl-2-propan-2-yl-1,2-dihydropyrrol-5-one'>A1AOZ</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7h63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7h63 OCA], [https://pdbe.org/7h63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7h63 RCSB], [https://www.ebi.ac.uk/pdbsum/7h63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7h63 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CMA1_HUMAN CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Banner DW]]
[[Category: Benz JM]]
[[Category: Hilpert H]]
[[Category: Schlatter D]]