View source for 7h65


==THE 1.8 A CRYSTAL STRUCTURE OF HUMAN CHYMASE IN COMPLEX WITH N-[1-[2-[[2-hydroxy-3-methyl-3-(4-methylphenyl)-4-oxocyclobuten-1-yl]-phenylmethyl]-6-methyl-1H-indol-3-yl]-2-methylpropan-2-yl]acetamide==
<StructureSection load='7h65' size='340' side='right'caption='[[7h65]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7h65]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7H65 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7H65 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1AO1:~{N}-[2-methyl-1-[6-methyl-2-[(~{R})-[(3~{S})-3-methyl-3-(4-methylphenyl)-2-oxidanyl-4-oxidanylidene-cyclobuten-1-yl]-phenyl-methyl]-1~{H}-indol-3-yl]propan-2-yl]ethanamide'>A1AO1</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7h65 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7h65 OCA], [https://pdbe.org/7h65 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7h65 RCSB], [https://www.ebi.ac.uk/pdbsum/7h65 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7h65 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CMA1_HUMAN CMA1_HUMAN] Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion.
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Banner DW]]
[[Category: Benz JM]]
[[Category: Hilpert H]]
[[Category: Schlatter D]]