View source for 7jh3


==Crystal structure of 4-aminobutyrate aminotransferase PuuE from Escherichia coli in complex with PLP==
<StructureSection load='7jh3' size='340' side='right'caption='[[7jh3]], [[Resolution|resolution]] 2.68&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7jh3]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JH3 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.68&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jh3 OCA], [https://pdbe.org/7jh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jh3 RCSB], [https://www.ebi.ac.uk/pdbsum/7jh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jh3 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PUUE_ECOLI PUUE_ECOLI] Catalyzes the transfer of the amino group from gamma-aminobutyrate (GABA) to alpha-ketoglutarate (KG) to yield succinic semialdehyde (SSA). PuuE is important for utilization of putrescine as the sole nitrogen or carbon source.<ref>PMID:15590624</ref> <ref>PMID:20639325</ref> 

==See Also==
*[[Aminotransferase 3D structures|Aminotransferase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli K-12]]
[[Category: Large Structures]]
[[Category: Di Leo R]]
[[Category: Evdokimova E]]
[[Category: Joachimiak A]]
[[Category: Satchell KJF]]
[[Category: Savchenko A]]
[[Category: Stogios PJ]]
[[Category: Valleau D]]