View source for 7jlv


==Structure of the activated Roq1 resistosome directly recognizing the pathogen effector XopQ==
<StructureSection load='7jlv' size='340' side='right'caption='[[7jlv]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7jlv]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nicotiana_benthamiana Nicotiana benthamiana]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JLV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JLV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jlv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jlv OCA], [https://pdbe.org/7jlv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jlv RCSB], [https://www.ebi.ac.uk/pdbsum/7jlv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jlv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ROQ1_NICBE ROQ1_NICBE] Disease resistance (R) protein that specifically recognizes the Xanthomonas and Pseudomonas effector proteins XopQ and HopQ1, and triggers cell death (PubMed:28891100). Acts as a NAD(+) hydrolase (NADase): in response to activation, catalyzes cleavage of NAD(+) into ADP-D-ribose (ADPR) and nicotinamide; NAD(+) cleavage triggering a defense system that promotes cell death (PubMed:31439792).<ref>PMID:28891100</ref> <ref>PMID:31439792</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Nicotiana benthamiana]]
[[Category: King M]]
[[Category: Lui F]]
[[Category: Martin R]]
[[Category: Nogales E]]
[[Category: Qi T]]
[[Category: Staskawicz BJ]]
[[Category: Toth C]]
[[Category: Zhang H]]