View source for 7jq8


==Solution NMR structure of human Brd3 ET domain==
<StructureSection load='7jq8' size='340' side='right'caption='[[7jq8]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7jq8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Moloney_murine_leukemia_virus_isolate_Shinnick Moloney murine leukemia virus isolate Shinnick]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JQ8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JQ8 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jq8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jq8 OCA], [https://pdbe.org/7jq8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jq8 RCSB], [https://www.ebi.ac.uk/pdbsum/7jq8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jq8 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Note=A chromosomal aberration involving BRD3 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;9)(q14;q34) with NUT which produces a BRD3-NUT fusion protein.
== Function ==
[https://www.uniprot.org/uniprot/BRD3_HUMAN BRD3_HUMAN] Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling and interaction with transcription factors. Regulates transcription by promoting the binding of the transcription factor GATA1 to its targets (By similarity). Regulates transcription of the CCND1 gene.<ref>PMID:18406326</ref> 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The extraterminal (ET) domain of BRD3 is conserved among BET proteins (BRD2, BRD3, BRD4), interacting with multiple host and viral protein-protein networks. Solution NMR structures of complexes formed between the BRD3 ET domain and either the 79-residue murine leukemia virus integrase (IN) C-terminal domain (IN329-408) or its 22-residue IN tail peptide (IN386-407) alone reveal similar intermolecular three-stranded beta-sheet formations. (15)N relaxation studies reveal a 10-residue linker region (IN379-388) tethering the SH3 domain (IN329-378) to the ET-binding motif (IN389-405):ET complex. This linker has restricted flexibility, affecting its potential range of orientations in the IN:nucleosome complex. The complex of the ET-binding peptide of the host NSD3 protein (NSD3148-184) and the BRD3 ET domain includes a similar three-stranded beta-sheet interaction, but the orientation of the beta hairpin is flipped compared with the two IN:ET complexes. These studies expand our understanding of molecular recognition polymorphism in complexes of ET-binding motifs with viral and host proteins.

A common binding motif in the ET domain of BRD3 forms polymorphic structural interfaces with host and viral proteins.,Aiyer S, Swapna GVT, Ma LC, Liu G, Hao J, Chalmers G, Jacobs BC, Montelione GT, Roth MJ Structure. 2021 Feb 13. pii: S0969-2126(21)00010-1. doi:, 10.1016/j.str.2021.01.010. PMID:33592170<ref>PMID:33592170</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7jq8" style="background-color:#fffaf0;"></div>

==See Also==
*[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Moloney murine leukemia virus isolate Shinnick]]
[[Category: Aiyer S]]
[[Category: Montelione GT]]
[[Category: Roth JM]]
[[Category: Swapna GVT]]