View source for 7jrg


==Plant Mitochondrial complex III2 from Vigna radiata==
<StructureSection load='7jrg' size='340' side='right'caption='[[7jrg]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7jrg]] is a 20 chain structure with sequence from [https://en.wikipedia.org/wiki/Vigna_radiata_var._radiata Vigna radiata var. radiata]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JRG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JRG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=CDL:CARDIOLIPIN'>CDL</scene>, <scene name='pdbligand=HEC:HEME+C'>HEC</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PC1:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE'>PC1</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jrg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jrg OCA], [https://pdbe.org/7jrg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jrg RCSB], [https://www.ebi.ac.uk/pdbsum/7jrg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jrg ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Mitochondrial complex III (CIII(2)) and complex IV (CIV), which can associate into a higher-order supercomplex (SC III(2)+IV), play key roles in respiration. However, structures of these plant complexes remain unknown. We present atomic models of CIII(2), CIV, and SC III(2)+IV from Vigna radiata determined by single-particle cryoEM. The structures reveal plant-specific differences in the MPP domain of CIII(2) and define the subunit composition of CIV. Conformational heterogeneity analysis of CIII(2) revealed long-range, coordinated movements across the complex, as well as the motion of CIII(2)'s iron-sulfur head domain. The CIV structure suggests that, in plants, proton translocation does not occur via the H channel. The supercomplex interface differs significantly from that in yeast and bacteria in its interacting subunits, angle of approach and limited interactions in the mitochondrial matrix. These structures challenge long-standing assumptions about the plant complexes and generate new mechanistic hypotheses.

Atomic structures of respiratory complex III(2), complex IV, and supercomplex III(2)-IV from vascular plants.,Maldonado M, Guo F, Letts JA Elife. 2021 Jan 19;10:e62047. doi: 10.7554/eLife.62047. PMID:33463523<ref>PMID:33463523</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7jrg" style="background-color:#fffaf0;"></div>

==See Also==
*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
*[[Cytochrome bc1 3D structures|Cytochrome bc1 3D structures]]
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Vigna radiata var. radiata]]
[[Category: Letts JA]]
[[Category: Maldonado M]]