View source for 7jrh


==X-ray crystal structure of a cyclic peptide containing medin(19-25) and medin(31-37)==
<StructureSection load='7jrh' size='340' side='right'caption='[[7jrh]], [[Resolution|resolution]] 1.32&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JRH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JRH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.32&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=MLE:N-METHYLLEUCINE'>MLE</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jrh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jrh OCA], [https://pdbe.org/7jrh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jrh RCSB], [https://www.ebi.ac.uk/pdbsum/7jrh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jrh ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Amyloidogenic peptides and proteins are rich sources of supramolecular assemblies. Sequences derived from well-known amyloids, including Abeta, human islet amyloid polypeptide, and tau have been found to assemble as fibrils, nanosheets, ribbons, and nanotubes. The supramolecular assembly of medin, a 50-amino acid peptide that forms fibrillary deposits in aging human vasculature, has not been heavily investigated. In this work, we present an X-ray crystallographic structure of a cyclic beta-sheet peptide derived from the 19-36 region of medin that assembles to form interpenetrating cubes. The edge of each cube is composed of a single peptide, and each vertex is occupied by a divalent metal ion. This structure may be considered a metal-organic framework (MOF) containing a large peptide ligand. This work demonstrates that peptides containing Glu or Asp that are preorganized to adopt beta-hairpin structures can serve as ligands and assemble with metal ions to form MOFs.

Interpenetrating Cubes in the X-ray Crystallographic Structure of a Peptide Derived from Medin19-36.,Howitz WJ, Wierzbicki M, Cabanela RW, Saliba C, Motavalli A, Tran N, Nowick JS J Am Chem Soc. 2020 Sep 3. doi: 10.1021/jacs.0c06143. PMID:32816461<ref>PMID:32816461</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7jrh" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Howitz WJ]]
[[Category: Nowick JS]]
[[Category: Wierzbicki M]]