View source for 7jsh


==Adeno-Associated Virus 2 Rep68 HD Heptamer-ssAAVS1 with ATPgS==
<StructureSection load='7jsh' size='340' side='right'caption='[[7jsh]], [[Resolution|resolution]] 4.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7jsh]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Adeno-associated_virus_2 Adeno-associated virus 2] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JSH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JSH FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jsh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jsh OCA], [https://pdbe.org/7jsh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jsh RCSB], [https://www.ebi.ac.uk/pdbsum/7jsh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jsh ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/REP68_AAV2S REP68_AAV2S] Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factor in site-specific integration of the viral genome. Inhibits the host cell cycle G1/S and G2/M transitions. These arrests may provide essential cellular factors for viral DNA replication.<ref>PMID:9882364</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Adeno-associated virus 2]]
[[Category: Large Structures]]
[[Category: Synthetic construct]]
[[Category: Escalante CR]]