View source for 7ju4


==Radial spoke 2 stalk, IDAc, and N-DRC attached with doublet microtubule==
<StructureSection load='7ju4' size='340' side='right'caption='[[7ju4]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ju4]] is a 37 chain structure with sequence from [https://en.wikipedia.org/wiki/Chlamydomonas_reinhardtii Chlamydomonas reinhardtii]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JU4 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ju4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ju4 OCA], [https://pdbe.org/7ju4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ju4 RCSB], [https://www.ebi.ac.uk/pdbsum/7ju4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ju4 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DRC2_CHLRE DRC2_CHLRE] Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (PubMed:23427265, PubMed:25411337). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules (PubMed:29167384).<ref>PMID:23427265</ref> <ref>PMID:25411337</ref> <ref>PMID:29167384</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Chlamydomonas reinhardtii]]
[[Category: Large Structures]]
[[Category: Berger B]]
[[Category: Brown A]]
[[Category: Davis J]]
[[Category: Dutcher S]]
[[Category: Gui M]]
[[Category: Koh F]]
[[Category: Ma M]]
[[Category: Sze-Tu E]]
[[Category: Wang X]]
[[Category: Zhang R]]
[[Category: Zhong E]]