View source for 7kc5


==X-ray structure of Lfa-1 I domain in complex with BMS-68852 collected at 273 K==
<StructureSection load='7kc5' size='340' side='right'caption='[[7kc5]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7kc5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KC5 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BJZ:6-[(5S,9R)-9-(4-CYANOPHENYL)-3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-DIOXO-1,3,7-TRIAZASPIRO[4.4]NON-7-YL]PYRIDINE-3-CARBOXYLIC+ACID'>BJZ</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kc5 OCA], [https://pdbe.org/7kc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kc5 RCSB], [https://www.ebi.ac.uk/pdbsum/7kc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kc5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.

==See Also==
*[[Integrin 3D structures|Integrin 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Akassoglou K]]
[[Category: Arkin MR]]
[[Category: Cortez SV]]
[[Category: Fraser JS]]
[[Category: Hallenbeck KK]]
[[Category: Kelly MJ]]
[[Category: Lee G]]
[[Category: Pfaff SJ]]
[[Category: Woldeyes RA]]