View source for 7krb


==Solution Structure of the Dysferlin C2A Domain in its Calcium-bound State==
<StructureSection load='7krb' size='340' side='right'caption='[[7krb]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7krb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KRB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KRB FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7krb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7krb OCA], [https://pdbe.org/7krb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7krb RCSB], [https://www.ebi.ac.uk/pdbsum/7krb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7krb ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN] Miyoshi myopathy;Distal myopathy with anterior tibial onset;Congenital myopathy, Paradas type;Autosomal recessive limb-girdle muscular dystrophy type 2B. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/DYSF_HUMAN DYSF_HUMAN] Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mercier P]]
[[Category: Santamaria L]]
[[Category: Shaw GS]]
[[Category: Wang Y]]