View source for 7ku7


==Cryo-EM structure of Rous sarcoma virus cleaved synaptic complex (CSC) with HIV-1 integrase strand transfer inhibitor MK-2048. Cluster identified by 3-dimensional variability analysis in cryoSPARC.==
<StructureSection load='7ku7' size='340' side='right'caption='[[7ku7]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ku7]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Rous_sarcoma_virus_(strain_Schmidt-Ruppin_A) Rous sarcoma virus (strain Schmidt-Ruppin A)]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KU7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KU7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=ZZX:(6S)-2-(3-CHLORO-4-FLUOROBENZYL)-8-ETHYL-10-HYDROXY-N,6-DIMETHYL-1,9-DIOXO-1,2,6,7,8,9-HEXAHYDROPYRAZINO[1,2 1,5]PYRROLO[2,3-D]PYRIDAZINE-4-CARBOXAMIDE'>ZZX</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ku7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ku7 OCA], [https://pdbe.org/7ku7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ku7 RCSB], [https://www.ebi.ac.uk/pdbsum/7ku7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ku7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/POL_RSVP POL_RSVP] Capsid protein p27 forms the spherical core of the virus that encapsulates the genomic RNA-nucleocapsid complex (By similarity).  The aspartyl protease mediates proteolytic cleavages of Gag and Gag-Pol polyproteins during or shortly after the release of the virion from the plasma membrane. Cleavages take place as an ordered, step-wise cascade to yield mature proteins. This process is called maturation. Displays maximal activity during the budding process just prior to particle release from the cell (By similarity).

==See Also==
*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
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</StructureSection>
[[Category: Large Structures]]
[[Category: Aihara H]]
[[Category: Bera S]]
[[Category: Grandgenett DP]]
[[Category: Pandey KK]]
[[Category: Shi K]]