View source for 7lbu


==Crystal structure of the Propionibacterium acnes surface sialidase==
<StructureSection load='7lbu' size='340' side='right'caption='[[7lbu]], [[Resolution|resolution]] 2.11&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LBU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LBU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.11&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lbu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lbu OCA], [https://pdbe.org/7lbu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lbu RCSB], [https://www.ebi.ac.uk/pdbsum/7lbu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lbu ProSAT]</span></td></tr>
</table>
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== Publication Abstract from PubMed ==
Propionibacterium acnes, though generally considered part of the normal flora of human skin, is an opportunistic pathogen associated with acne vulgaris as well as other diseases, including endocarditis, endophthalmitis and prosthetic joint infections. Its virulence potential is also supported by knowledge gained from its sequenced genome. Indeed, a vaccine targeting a putative cell wall-anchored P. acnes sialidase has been shown to suppress cytotoxicity and pro-inflammatory cytokine release induced by the organism, and is proposed as an alternative treatment for P. acnes-associated diseases. Here, we report the crystal structures of the surface sialidase and its complex with the transition-state mimic Neu5Ac2en. Our structural and kinetic analyses, together with insight from a glycan array screen, which probes subtle specificities of the sialidase for alpha-2,3-sialosides, provide a basis for the structure-based design of novel small-molecule therapeutics against P. acnes infections.

Crystal structure of the Propionibacterium acnes surface sialidase, a drug target for P. acnes-associated diseases.,Yu ACY, Volkers G, Jongkees SAK, Worrall LJ, Withers SG, Strynadka NCJ Glycobiology. 2021 Nov 17. pii: 6430129. doi: 10.1093/glycob/cwab094. PMID:34792586<ref>PMID:34792586</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Strynadka NCJ]]
[[Category: Volkers G]]
[[Category: Yu ACY]]