View source for 7lg1


==Cryo-EM structure of human cGMP-bound CNGA1_E365Q channel in Na+/Ca2+==
<StructureSection load='7lg1' size='340' side='right'caption='[[7lg1]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7lg1]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LG1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LG1 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PCG:CYCLIC+GUANOSINE+MONOPHOSPHATE'>PCG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lg1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lg1 OCA], [https://pdbe.org/7lg1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lg1 RCSB], [https://www.ebi.ac.uk/pdbsum/7lg1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lg1 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/CNGA1_HUMAN CNGA1_HUMAN] Retinitis pigmentosa. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/CNGA1_HUMAN CNGA1_HUMAN] Subunit of the rod cyclic GMP-gated cation channel, which is involved in the final stage of the phototransduction pathway. When light hits rod photoreceptors, cGMP concentrations decrease causing rapid closure of CNGA1/CNGB1 channels and, therefore, hyperpolarization of the membrane potential.[UniProtKB:Q00194]

==See Also==
*[[Ion channels 3D structures|Ion channels 3D structures]]
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Han Y]]
[[Category: Jiang Y]]
[[Category: Xue J]]