View source for 7lix


==CaRSP1 and scaffolded phycoerythrin beta subunits from the phycobilisome of Porphyridium purpureum==
<StructureSection load='7lix' size='340' side='right'caption='[[7lix]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7lix]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyridium_purpureum Porphyridium purpureum]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LIX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LIX FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MEN:N-METHYL+ASPARAGINE'>MEN</scene>, <scene name='pdbligand=PEB:PHYCOERYTHROBILIN'>PEB</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lix FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lix OCA], [https://pdbe.org/7lix PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lix RCSB], [https://www.ebi.ac.uk/pdbsum/7lix PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lix ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A5J4YJY8_PORPP A0A5J4YJY8_PORPP] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Photosynthetic organisms have developed diverse antennas composed of chromophorylated proteins to increase photon capture. Cryptophyte algae acquired their photosynthetic organelles (plastids) from a red alga by secondary endosymbiosis. Cryptophytes lost the primary red algal antenna, the red algal phycobilisome, replacing it with a unique antenna composed of alphabeta protomers, where the beta subunit originates from the red algal phycobilisome. The origin of the cryptophyte antenna, particularly the unique alpha subunit, is unknown. Here we show that the cryptophyte antenna evolved from a complex between a red algal scaffolding protein and phycoerythrin beta. Published cryo-EM maps for two red algal phycobilisomes contain clusters of unmodelled density homologous to the cryptophyte-alphabeta protomer. We modelled these densities, identifying a new family of scaffolding proteins related to red algal phycobilisome linker proteins that possess multiple copies of a cryptophyte-alpha-like domain. These domains bind to, and stabilise, a conserved hydrophobic surface on phycoerythrin beta, which is the same binding site for its primary partner in the red algal phycobilisome, phycoerythrin alpha. We propose that after endosymbiosis these scaffolding proteins outcompeted the primary binding partner of phycoerythrin beta, resulting in the demise of the red algal phycobilisome and emergence of the cryptophyte antenna.

Scaffolding proteins guide the evolution of algal light harvesting antennas.,Rathbone HW, Michie KA, Landsberg MJ, Green BR, Curmi PMG Nat Commun. 2021 Mar 25;12(1):1890. doi: 10.1038/s41467-021-22128-w. PMID:33767155<ref>PMID:33767155</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7lix" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Porphyridium purpureum]]
[[Category: Curmi PMG]]
[[Category: Green BR]]
[[Category: Landsberg MJ]]
[[Category: Michie KA]]
[[Category: Rathbone HW]]