View source for 7ml6


==Structure of CalU17 from the Calicheamicin Biosynthesis Pathway of Micromonospora echinospora==
<StructureSection load='7ml6' size='340' side='right'caption='[[7ml6]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ml6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Micromonospora_echinospora Micromonospora echinospora]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ML6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ML6 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ml6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ml6 OCA], [https://pdbe.org/7ml6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ml6 RCSB], [https://www.ebi.ac.uk/pdbsum/7ml6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ml6 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q8KND1_MICEC Q8KND1_MICEC] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Dynemicin is an enediyne natural product from Micromonospora chersina ATCC53710. Access to the biosynthetic gene cluster of dynemicin has enabled the in vitro study of gene products within the cluster to decipher their roles in assembling this unique molecule. This paper reports the crystal structure of DynF, the gene product of one of the genes within the biosynthetic gene cluster of dynemicin. DynF is revealed to be a dimeric eight-stranded beta-barrel structure with palmitic acid bound within a cavity. The presence of palmitic acid suggests that DynF may be involved in binding the precursor polyene heptaene, which is central to the synthesis of the ten-membered ring of the enediyne core.

The crystal structure of DynF from the dynemicin-biosynthesis pathway of Micromonospora chersina.,Kosgei AJ, Miller MD, Bhardwaj M, Xu W, Thorson JS, Van Lanen SG, Phillips GN Jr Acta Crystallogr F Struct Biol Commun. 2022 Jan 1;78(Pt 1):1-7. doi:, 10.1107/S2053230X21012322. Epub 2022 Jan 1. PMID:34981769<ref>PMID:34981769</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7ml6" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Micromonospora echinospora]]
[[Category: Kosgei AJ]]
[[Category: Miller MD]]
[[Category: Phillips Jr GN]]
[[Category: Thorson JS]]
[[Category: Van Lanen SG]]
[[Category: Xu W]]