View source for 7mrj


==Crystal structure of a novel ubiquitin-like TINCR==
<StructureSection load='7mrj' size='340' side='right'caption='[[7mrj]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7mrj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MRJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MRJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mrj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mrj OCA], [https://pdbe.org/7mrj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mrj RCSB], [https://www.ebi.ac.uk/pdbsum/7mrj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mrj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TINCR_HUMAN TINCR_HUMAN] 
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The TINCR (Terminal differentiation-Induced Non-Coding RNA) gene is selectively expressed in epithelium tissues and is involved in the control of human epidermal differentiation and wound healing. Despite its initial report as a long non-coding RNA, the TINCR locus codes for a highly conserved ubiquitin-like microprotein associated with keratinocyte differentiation. Here we report the identification of TINCR as a tumor suppressor in squamous cell carcinoma (SCC). TINCR is upregulated by UV-induced DNA damage in a TP53-dependent manner in human keratinocytes. Decreased TINCR protein expression is prevalently found in skin and head and neck squamous cell tumors and TINCR expression suppresses the growth of SCC cells in vitro and in vivo. Consistently, Tincr knockout mice show accelerated tumor development following UVB skin carcinogenesis and increased penetrance of invasive SCCs. Finally, genetic analyses identify loss-of-function mutations and deletions encompassing the TINCR gene in SCC clinical samples supporting a tumor suppressor role in human cancer. Altogether, these results demonstrate a role for TINCR as protein coding tumor suppressor gene recurrently lost in squamous cell carcinomas.

The TINCR ubiquitin-like microprotein is a tumor suppressor in squamous cell carcinoma.,Morgado-Palacin L, Brown JA, Martinez TF, Garcia-Pedrero JM, Forouhar F, Quinn SA, Reglero C, Vaughan J, Heydary YH, Donaldson C, Rodriguez-Perales S, Allonca E, Granda-Diaz R, Fernandez AF, Fraga MF, Kim AL, Santos-Juanes J, Owens DM, Rodrigo JP, Saghatelian A, Ferrando AA Nat Commun. 2023 Mar 10;14(1):1328. doi: 10.1038/s41467-023-36713-8. PMID:36899004<ref>PMID:36899004</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7mrj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Allonca E]]
[[Category: Brown JA]]
[[Category: Chaudhry I]]
[[Category: Fernandez AF]]
[[Category: Ferrando AA]]
[[Category: Forouhar F]]
[[Category: Fraga MF]]
[[Category: Granda-Diaz R]]
[[Category: Kim AL]]
[[Category: Martinez T]]
[[Category: Morgado-Palacin L]]
[[Category: Owens DM]]
[[Category: Pedrero JMG]]
[[Category: Quinn SA]]
[[Category: Reglero C]]
[[Category: Rodrigo JP]]
[[Category: Rodriguez-Perales S]]
[[Category: Saghatelian A]]
[[Category: Santos-Juanes J]]
[[Category: Vaughan J]]