View source for 7omw


==Thermus sp. 2.9 DarT in complex with NAD+==
<StructureSection load='7omw' size='340' side='right'caption='[[7omw]], [[Resolution|resolution]] 1.30&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7omw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_sp._2.9 Thermus sp. 2.9]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OMW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OMW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7omw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7omw OCA], [https://pdbe.org/7omw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7omw RCSB], [https://www.ebi.ac.uk/pdbsum/7omw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7omw ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DART_THES0 DART_THES0] Toxic component of a hybrid type II/IV toxin-antitoxin (TA) system. ADP-ribosylates ssDNA on the second thymidine of the consensus sequence 5'-TNTC-3'; the protein does not auto-modify. Arg-51 is highly flexible, allowing it to assume multiple positions in the crystal structures (PubMed:34408320). Its toxic effect is neutralized by cognate antitoxin DarG (By similarity).[UniProtKB:O53604]<ref>PMID:34408320</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Large Structures]]
[[Category: Thermus sp. 2 9]]
[[Category: Ariza A]]
[[Category: Schuller M]]