View source for 7ons


==PARP1 catalytic domain in complex with isoquinolone-based inhibitor (compound 16)==
<StructureSection load='7ons' size='340' side='right'caption='[[7ons]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ons]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ONS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ONS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.97&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=VKT:7-[[4-(1,5-dimethylimidazol-2-yl)piperazin-1-yl]methyl]-3-ethyl-1~{H}-quinolin-2-one'>VKT</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ons FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ons OCA], [https://pdbe.org/7ons PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ons RCSB], [https://www.ebi.ac.uk/pdbsum/7ons PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ons ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PARP1_HUMAN PARP1_HUMAN] Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks. Mediates the poly(ADP-ribosyl)ation of APLF and CHFR. Positively regulates the transcription of MTUS1 and negatively regulates the transcription of MTUS2/TIP150. With EEF1A1 and TXK, forms a complex that acts as a T-helper 1 (Th1) cell-specific transcription factor and binds the promoter of IFN-gamma to directly regulate its transcription, and is thus involved importantly in Th1 cytokine production.<ref>PMID:17177976</ref> <ref>PMID:18172500</ref> <ref>PMID:19344625</ref> <ref>PMID:19661379</ref> 

==See Also==
*[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Balazs A]]
[[Category: Barratt D]]
[[Category: Bista M]]
[[Category: Chuba M]]
[[Category: Degorce SL]]
[[Category: Di Fruscia P]]
[[Category: Embrey K]]
[[Category: Ghosh A]]
[[Category: Gill S]]
[[Category: Gunnarsson A]]
[[Category: Hande S]]
[[Category: Heightman TD]]
[[Category: Hemsley P]]
[[Category: Illuzzi G]]
[[Category: Johannes JW]]
[[Category: Lane J]]
[[Category: Larner C]]
[[Category: Leo E]]
[[Category: Madin A]]
[[Category: Martin S]]
[[Category: McWilliams L]]
[[Category: Orme J]]
[[Category: Pachl F]]
[[Category: Packer M]]
[[Category: Pike A]]
[[Category: Schimpl M]]
[[Category: Staniszewska AD]]
[[Category: Talbot V]]
[[Category: Underwood E]]
[[Category: Varnes GJ]]
[[Category: Zhang A]]
[[Category: Zheng X]]