View source for 7oqs


==Ternary complex of 14-3-3 sigma, Amot-p130 phosphopeptide, and WQ177==
<StructureSection load='7oqs' size='340' side='right'caption='[[7oqs]], [[Resolution|resolution]] 1.34&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7oqs]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OQS FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.34&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=0BS:2-(1,3-benzodioxol-5-yl)-~{N}-[(5-carbamimidoyl-3-phenyl-thiophen-2-yl)methyl]ethanamide'>0BS</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SEP:PHOSPHOSERINE'>SEP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7oqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7oqs OCA], [https://pdbe.org/7oqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7oqs RCSB], [https://www.ebi.ac.uk/pdbsum/7oqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7oqs ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/AMOT_HUMAN AMOT_HUMAN] Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions.<ref>PMID:11257124</ref> <ref>PMID:16678097</ref> 

==See Also==
*[[14-3-3 protein 3D structures|14-3-3 protein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Centorrino F]]
[[Category: Ottmann C]]