View source for 7ovq


==Immature HIV-1 matrix structure==
<StructureSection load='7ovq' size='340' side='right'caption='[[7ovq]], [[Resolution|resolution]] 7.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7OVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7OVQ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 7.2&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MYR:MYRISTIC+ACID'>MYR</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ovq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ovq OCA], [https://pdbe.org/7ovq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ovq RCSB], [https://www.ebi.ac.uk/pdbsum/7ovq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ovq ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Gag, the primary structural protein of HIV-1, is recruited to the plasma membrane for virus assembly by its matrix (MA) domain. Gag is subsequently cleaved into its component domains, causing structural maturation to repurpose the virion for cell entry. We determined the structure and arrangement of MA within immature and mature HIV-1 through cryo-electron tomography. We found that MA rearranges between two different hexameric lattices upon maturation. In mature HIV-1, a lipid extends out of the membrane to bind with a pocket in MA. Our data suggest that proteolytic maturation of HIV-1 not only assembles the viral capsid surrounding the genome but also repurposes the membrane-bound MA lattice for an entry or postentry function and results in the partial removal of up to 2500 lipids from the viral membrane.

Maturation of the matrix and viral membrane of HIV-1.,Qu K, Ke Z, Zila V, Anders-Osswein M, Glass B, Mucksch F, Muller R, Schultz C, Muller B, Krausslich HG, Briggs JAG Science. 2021 Aug 6;373(6555):700-704. doi: 10.1126/science.abe6821. PMID:34353956<ref>PMID:34353956</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7ovq" style="background-color:#fffaf0;"></div>

==See Also==
*[[Gag polyprotein 3D structures|Gag polyprotein 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Anders-Oesswein M]]
[[Category: Briggs JAG]]
[[Category: Glass B]]
[[Category: Ke ZL]]
[[Category: Kraeusslich HG]]
[[Category: Muecksch F]]
[[Category: Mueller B]]
[[Category: Mueller R]]
[[Category: Qu K]]
[[Category: Schultz C]]
[[Category: Zila V]]