View source for 7p57


==VSG2 mutant structure lacking the calcium binding pocket==
<StructureSection load='7p57' size='340' side='right'caption='[[7p57]], [[Resolution|resolution]] 1.96&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7p57]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Trypanosoma_brucei_brucei Trypanosoma brucei brucei]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7P57 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7P57 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.961&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7p57 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7p57 OCA], [https://pdbe.org/7p57 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7p57 RCSB], [https://www.ebi.ac.uk/pdbsum/7p57 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7p57 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VSM2_TRYBB VSM2_TRYBB] VSG forms a coat on the surface of the parasite. The trypanosome evades the immune response of the host by expressing a series of antigenically distinct VSGs from an estimated 1000 VSG genes.
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</StructureSection>
[[Category: Large Structures]]
[[Category: Trypanosoma brucei brucei]]
[[Category: Aresta-Branco F]]
[[Category: Gkeka A]]
[[Category: Papavasiliou FN]]
[[Category: Stebbins CE]]