View source for 7pdj


==R12E vFLIP mutant==
<StructureSection load='7pdj' size='340' side='right'caption='[[7pdj]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7pdj]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_gammaherpesvirus_8 Human gammaherpesvirus 8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PDJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PDJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pdj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pdj OCA], [https://pdbe.org/7pdj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pdj RCSB], [https://www.ebi.ac.uk/pdbsum/7pdj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pdj ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VFLIP_HHV8P VFLIP_HHV8P] Plays a role in the modulation of host signaling pathways by acting as an activator of both the classic and the alternative NF-kappa-B pathways. Thereby, initiates an important range of cellular processes to promote cell survival, proliferation and protection from apoptosis.<ref>PMID:10523854</ref> <ref>PMID:16311516</ref> <ref>PMID:29698475</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Human gammaherpesvirus 8]]
[[Category: Large Structures]]
[[Category: Barrett TE]]