View source for 7plp


==Human Teneurin-4 C-rich domain==
<StructureSection load='7plp' size='340' side='right'caption='[[7plp]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7plp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PLP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PLP FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=FE:FE+(III)+ION'>FE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7plp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7plp OCA], [https://pdbe.org/7plp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7plp RCSB], [https://www.ebi.ac.uk/pdbsum/7plp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7plp ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TEN4_HUMAN TEN4_HUMAN] NON RARE IN EUROPE: Hereditary essential tremor. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/TEN4_HUMAN TEN4_HUMAN] Involved in neural development, regulating the establishment of proper connectivity within the nervous system. Plays a role in the establishment of the anterior-posterior axis during gastrulation. Regulates the differentiation and cellular process formation of oligodendrocytes and myelination of small-diameter axons in the central nervous system (CNS) (PubMed:26188006). Promotes activation of focal adhesion kinase. May function as a cellular signal transducer (By similarity).[UniProtKB:Q3UHK6]<ref>PMID:26188006</ref> 
== References ==
<references/>
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Beugelink JW]]
[[Category: Janssen BJC]]
[[Category: Meijer DH]]