View source for 7pqw


==NMR solution structure of BCR4==
<StructureSection load='7pqw' size='340' side='right'caption='[[7pqw]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7pqw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Acyrthosiphon_pisum Acyrthosiphon pisum]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7PQW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7PQW FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7pqw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7pqw OCA], [https://pdbe.org/7pqw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7pqw RCSB], [https://www.ebi.ac.uk/pdbsum/7pqw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7pqw ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Aphids (Hemiptera: Aphidoidea) are among the most detrimental insects for agricultural plants, and their management is a great challenge in agronomical research. A new class of proteins, called Bacteriocyte-specific Cysteine-Rich (BCR) peptides, provides an alternative to chemical insecticides for pest control. BCRs were initially identified in the pea aphid Acyrthosiphon pisum. They are small disulfide bond-rich proteins expressed exclusively in aphid bacteriocytes, the insect cells that host intracellular symbiotic bacteria. Here, we show that one of the A. pisum BCRs, BCR4, displays prominent insecticidal activity against the pea aphid, impairing insect survival and nymphal growth, providing evidence for its potential use as a new biopesticide. Our comparative genomics and phylogenetic analyses indicate that BCRs are restricted to the aphid lineage. The 3D structure of BCR4 reveals that this peptide belongs to an as-yet-unknown structural class of peptides and defines a new superfamily of defensins.

Aphid BCR4 Structure and Activity Uncover a New Defensin Peptide Superfamily.,Loth K, Parisot N, Paquet F, Terrasson H, Sivignon C, Rahioui I, Ribeiro Lopes M, Gaget K, Duport G, Delmas AF, Aucagne V, Heddi A, Calevro F, da Silva P Int J Mol Sci. 2022 Oct 18;23(20):12480. doi: 10.3390/ijms232012480. PMID:36293341<ref>PMID:36293341</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7pqw" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
[[Category: Acyrthosiphon pisum]]
[[Category: Large Structures]]
[[Category: Loth K]]
[[Category: Paquet F]]