View source for 7q4i


==Crystal structure of DmC1GalT1 in complex with UDP-Mn2+ and the APD-TGalNAc-RP==
<StructureSection load='7q4i' size='340' side='right'caption='[[7q4i]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7q4i]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7Q4I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7Q4I FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=LPD:L-PROLINAMIDE'>LPD</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7q4i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7q4i OCA], [https://pdbe.org/7q4i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7q4i RCSB], [https://www.ebi.ac.uk/pdbsum/7q4i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7q4i ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C1GLT_DROME C1GLT_DROME] Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.<ref>PMID:18985719</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Drosophila melanogaster]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Clausen H]]
[[Category: Coelho H]]
[[Category: Companon I]]
[[Category: Corzana F]]
[[Category: Gonzalez-Ramirez AM]]
[[Category: Grosso AS]]
[[Category: Hurtado-Guerrero R]]
[[Category: Marcelo F]]
[[Category: Narimatsu Y]]
[[Category: Yang Z]]