View source for 7qe7


==High-resolution structure of the Anaphase-promoting complex/cyclosome (APC/C) bound to co-activator Cdh1==
<StructureSection load='7qe7' size='340' side='right'caption='[[7qe7]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7qe7]] is a 13 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QE7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QE7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qe7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qe7 OCA], [https://pdbe.org/7qe7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qe7 RCSB], [https://www.ebi.ac.uk/pdbsum/7qe7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qe7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/APC10_HUMAN APC10_HUMAN] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.<ref>PMID:18485873</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Barford D]]
[[Category: Boland A]]
[[Category: Chang L]]
[[Category: Hoefler A]]
[[Category: Yang J]]
[[Category: Yu J]]
[[Category: Zhang Z]]