View source for 7quj


==Structure of NsNEPS2, a 7S-cis-trans nepetalactone synthase==
<StructureSection load='7quj' size='340' side='right'caption='[[7quj]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7quj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Nepeta_sibirica Nepeta sibirica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QUJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QUJ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7quj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7quj OCA], [https://pdbe.org/7quj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7quj RCSB], [https://www.ebi.ac.uk/pdbsum/7quj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7quj ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Thousands of natural products are derived from the fused cyclopentane-pyran molecular scaffold nepetalactol. These natural products are used in an enormous range of applications that span the agricultural and medical industries. For example, nepetalactone, the oxidized derivative of nepetalactol, is known for its cat attractant properties as well as potential as an insect repellent. Most of these naturally occurring nepetalactol-derived compounds arise from only two out of the eight possible stereoisomers, 7S-cis-trans and 7R-cis-cis nepetalactols. Here we use a combination of naturally occurring and engineered enzymes to produce seven of the eight possible nepetalactol or nepetalactone stereoisomers. These enzymes open the possibilities for biocatalytic production of a broader range of iridoids, providing a versatile system for the diversification of this important natural product scaffold.

Biocatalytic routes to stereo-divergent iridoids.,Hernandez Lozada NJ, Hong B, Wood JC, Caputi L, Basquin J, Chuang L, Kunert M, Rodriguez Lopez CE, Langley C, Zhao D, Buell CR, Lichman BR, O'Connor SE Nat Commun. 2022 Aug 11;13(1):4718. doi: 10.1038/s41467-022-32414-w. PMID:35953485<ref>PMID:35953485</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7quj" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Nepeta sibirica]]
[[Category: Basquin J]]
[[Category: Buell CR]]
[[Category: Caputi L]]
[[Category: Chuang L]]
[[Category: Hernandez Lozada NJ]]
[[Category: Hong B]]
[[Category: Kunert M]]
[[Category: Langley C]]
[[Category: Lichman BR]]
[[Category: O'Connor SE]]
[[Category: Rodriguez Lopez CR]]
[[Category: Wood JC]]
[[Category: Zhao D]]