View source for 7qvm


==Human Oxytocin receptor (OTR) oxytocin Gq chimera (mGoqi) complex==
<StructureSection load='7qvm' size='340' side='right'caption='[[7qvm]], [[Resolution|resolution]] 3.25&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7qvm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QVM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QVM FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.25&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qvm OCA], [https://pdbe.org/7qvm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qvm RCSB], [https://www.ebi.ac.uk/pdbsum/7qvm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qvm ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN] Early infantile epileptic encephalopathy. The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/GNAO_HUMAN GNAO_HUMAN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(o) protein function is not clear. Stimulated by RGS14.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The small cyclic neuropeptide hormone oxytocin (OT) and its cognate receptor play a central role in the regulation of social behaviour and sexual reproduction. Here we report the single-particle cryo-electron microscopy structure of the active oxytocin receptor (OTR) in complex with its cognate ligand oxytocin. Our structure provides high-resolution insights into the OT binding mode, the OTR activation mechanism as well as the subtype specificity within the oxytocin/vasopressin receptor family.

Structural basis for the activation and ligand recognition of the human oxytocin receptor.,Waltenspuhl Y, Ehrenmann J, Vacca S, Thom C, Medalia O, Pluckthun A Nat Commun. 2022 Jul 18;13(1):4153. doi: 10.1038/s41467-022-31325-0. PMID:35851571<ref>PMID:35851571</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7qvm" style="background-color:#fffaf0;"></div>

==See Also==
*[[Transducin 3D structures|Transducin 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Ehrenmann J]]
[[Category: Medalia O]]
[[Category: Pluckthun A]]
[[Category: Thom C]]
[[Category: Vacca S]]
[[Category: Waltenspuhl Y]]