View source for 7qwv


==Crystal structure of the REC114-TOPOVIBL complex.==
<StructureSection load='7qwv' size='340' side='right'caption='[[7qwv]], [[Resolution|resolution]] 2.26&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7qwv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7QWV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7QWV FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.26&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7qwv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7qwv OCA], [https://pdbe.org/7qwv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7qwv RCSB], [https://www.ebi.ac.uk/pdbsum/7qwv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7qwv ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RE114_MOUSE RE114_MOUSE] Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination (PubMed:20551173, PubMed:27723721). Probably acts by forming a complex with IHO1/CCDC36 and MEI4, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis (PubMed:27723721).<ref>PMID:20551173</ref> <ref>PMID:27723721</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Juarez-Martinez AB]]
[[Category: Kadlec J]]
[[Category: Robert T]]
[[Category: De Massy B]]