View source for 7r2w


==Mutant S-adenosylmethionine synthetase from E.coli complexed with AMPPNP and methionine==
<StructureSection load='7r2w' size='340' side='right'caption='[[7r2w]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7r2w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R2W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R2W FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r2w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r2w OCA], [https://pdbe.org/7r2w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r2w RCSB], [https://www.ebi.ac.uk/pdbsum/7r2w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r2w ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/C3SV92_ECOLX C3SV92_ECOLX] Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.[HAMAP-Rule:MF_00086]

==See Also==
*[[S-adenosylmethionine synthetase 3D structures|S-adenosylmethionine synthetase 3D structures]]
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Bershtein S]]
[[Category: Kleiner D]]
[[Category: Shahar A]]
[[Category: Zarivach R]]