View source for 7r4p


==Structure of human hydroxyacid oxidase 1 bound with 6-amino-1-benzyl-5-(methylamino)pyrimidine-2,4(1H,3H)-dione==
<StructureSection load='7r4p' size='340' side='right'caption='[[7r4p]], [[Resolution|resolution]] 1.37&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7r4p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R4P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R4P FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.37&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=I2Z:6-amino-1-benzyl-5-(methylamino)pyrimidine-2,4(1H,3H)-dione'>I2Z</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r4p OCA], [https://pdbe.org/7r4p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r4p RCSB], [https://www.ebi.ac.uk/pdbsum/7r4p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r4p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/HAOX1_HUMAN HAOX1_HUMAN] Has 2-hydroxyacid oxidase activity. Most active on the 2-carbon substrate glycolate, but is also active on 2-hydroxy fatty acids, with high activity towards 2-hydroxy palmitate and 2-hydroxy octanoate.

==See Also==
*[[Glycolate oxidase 3D structures|Glycolate oxidase 3D structures]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bezerra GA]]
[[Category: Bountra C]]
[[Category: Bradley AR]]
[[Category: Brandeo-Neto J]]
[[Category: Brennan PE]]
[[Category: Douangamath A]]
[[Category: Edwards A]]
[[Category: Krojer T]]
[[Category: Mackinnon S]]
[[Category: Oppermann U]]
[[Category: Talon R]]
[[Category: Yue WW]]
[[Category: Von Delft F]]