View source for 7r51


==Structure of P. gingivalis DPP11 in complex with the dipeptide Arg-Asp==
<StructureSection load='7r51' size='340' side='right'caption='[[7r51]], [[Resolution|resolution]] 1.81&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7r51]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7R51 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7R51 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.808&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7r51 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7r51 OCA], [https://pdbe.org/7r51 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7r51 RCSB], [https://www.ebi.ac.uk/pdbsum/7r51 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7r51 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/DPP11_PORG3 DPP11_PORG3] Catalyzes the removal of dipeptides from the N-terminus of oligopeptides. Shows a strict specificity for acidic residues (Asp or Glu) in the P1 position, and has a hydrophobic residue preference at the P2 position. Preferentially cleaves the synthetic substrate Leu-Asp-methylcoumaryl-7-amide (Leu-Asp-MCA) as compared to Leu-Glu-MCA. Is involved in amino acid metabolism and bacterial growth of asaccharolytic P.gingivalis, that utilizes amino acids from extracellular proteinaceous nutrients as energy and carbon sources.<ref>PMID:21896480</ref> <ref>PMID:23246913</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Porphyromonas gingivalis]]
[[Category: Bezerra GA]]
[[Category: Bountra C]]
[[Category: Coker JA]]
[[Category: Foster WR]]
[[Category: Nemoto TK]]
[[Category: Ohara-Nemoto Y]]
[[Category: Tham CT]]
[[Category: Yue WW]]